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UF Health University of Florida
Martha L. Campbell-Thompson Laboratory Department of Pathology, Immunology & Laboratory Medicine
Molecular Pathology Core

Publications

Dr. Campbell-Thompson’s NCBI bibliography
  1. Campbell-Thompson, ML, Montgomery EL, Foss RM, Kolheffer KM, Phipps G, Schneider L, Atkinson MA. Collection protocol for human pancreas. Journal Visual Experimentation, 2012 May 23;(63). pii: 4039. doi: 10.3791/4039. PMID:22665046. (Editors’ Picks list)
  2. Campbell-Thompson ML, Heiple T, Montgomery E, Zhang L, Schneider L. Staining protocols for human pancreatic islets. Journal Visual Experimentation, 2012 May 23;(63). pii: 4068. doi: 10.3791/4068. PMID: 22665223
  3. Campbell-Thompson, M., C. Wasserfall, J. Kaddis, A. Albanese-O’Neill, T. Staeva, C. Nierras, J. Moraski, P. Rowe, R. Gianani, G. Eisenbarth, J. Crawford, D. Schatz, A. Pugliese, and M. Atkinson. Network for Pancreatic Organ Donors with Diabetes (nPOD): Developing a Tissue Biobank for Type 1 Diabetes. Diabetes/Metabolism Research and Reviews, May 14. doi: 10.1002/dmrr.2316. PMCID:PMC3456997.
  4. Campbell-Thompson M, Wasserfall C, Montgomery EL, Atkinson MA, Kaddis JS. Pancreas Organ Weight in Autoantibody Positive Individuals at Risk for Type 1 Diabetes. JAMA. 2012 Dec 12;308(22):2337-9. doi: 10.1001/jama.2012.15008. No abstract available. PMID: 23232891
  5. Butler AE, Campbell-Thompson M, Gurlo T, Dawson DW, Atkinson M, Butler PC. Marked Expansion of Exocrine and Endocrine Pancreas with Incretin Therapy in Humans with increased Exocrine Pancreas Dysplasia and the potential for Glucagon-producing Neuroendocrine Tumors. Diabetes. 2013. doi: 10.2337/db12-1686. PubMed PMID: 23524641.
  6. Christian Mueller, Jeffrey Chulay, Bruce Trapnell, Margaret Humphries, Brenna Carey, Robert Sandhaus, Noel G. McElvaney, Louis Messina, Qiushi Tang, Farshid Rouhani, Martha Campbell-Thompson, Anthony Yachnis, David Knop, Guo-jie Ye, Mark Brantly, Roberto Calcedo, Suryanarayan Somanathan, Lee Richman, Robert Vonderheide, James M. Wilson, Terence Flotte. Persistence of Transgene Expression Associated With In Situ Regulatory T Cell Responses in Humans 12 Months After Administration of Recombinant Adeno-Associated Virus Vector. JCI, 123:12:5310-
  7. Campbell-Thompson ML, Atkinson MA, Butler AE, Chapman NM, Frisk G, Gianani R, Giepmans BN, von Herrath MG, Hyöty H, Kay TW, Korsgren O, Morgan NG, Powers AC, Pugliese A, Richardson SJ, Rowe PA, Tracy S, In’t Veld PA. The diagnosis of insulitis in human type 1 diabetes. Diabetologia. 2013 Nov;56(11):2541-3. doi: 10.1007/s00125-013-3043-5. Epub 2013 Sep 5. PMID:24006089.
  8. Rowe P, Wasserfall C, Croker B, Campbell-Thompson M, Pugliese A, Atkinson M, Schatz D. Increased complement activation in human type 1 diabetes pancreata. Diabetes Care. 2013 Nov;36(11):3815-7. doi: 10.2337/dc13-0203. Epub 2013 Sep 16.
  9. Butler AE, Campbell-Thompson M, Gurlo T, Dawson DW, Atkinson M, Butler PC. Response to Comments on: Butler et al. Marked Expansion of Exocrine and Endocrine Pancreas With Incretin Therapy in Humans With Increased Exocrine Pancreas Dysplasia and the Potential for Glucagon-Producing Neuroendocrine Tumors. Diabetes 2013;62:2595-2604. PMCID: PMC3712065
  10. Mueller C, Chulay JD, Trapnell BC, Humphries M, Carey B, Sandhaus RA, McElvaney NG, Messina L, Tang Q, Rouhani FN, Campbell-Thompson M, Fu AD, Yachnis A, Knop DR, Ye GJ, Brantly M, Calcedo R, Somanathan S, Richman LP, Vonderheide RH, Hulme MA, Brusko TM, Wilson JM, Flotte TR. Human Treg responses allow sustained recombinant adeno-associated virus-mediated transgene expression. J Clin Invest 2013 123(12):5310-8.
  11. Pugliese A, Yang M, Kusmarteva I, Heiple T, Vendrame F, Wasserfall C, Rowe P, Moraski JM, Ball S, Jebson L, Schatz DA, Gianani R, Burke GW, Nierras C, Staeva T, Kaddis JS, Campbell-Thompson M, Atkinson MA. The Juvenile Diabetes Research Foundation Network for Pancreatic Organ Donors with Diabetes (nPOD) Program: goals, operational model and emerging findings. Peds Diabetes 2014 Feb;15(1):1-9. doi: 10.1111/pedi.12097. Epub 2013 Dec 10.
  12. Steinau M, Mona Saraiya, Marc T. Goodman, Edward S. Peters, Meg Watson, Jennifer L. Cleveland, Charles F. Lynch, Edward J. Wilkinson, Brenda Y. Hernandez, Glen Copeland, Maria S. Saber, Claudia Hopenhayn, Youjie Huang, Wendy Cozen, Christopher Lyu, Elizabeth R. Unger, and the HPV Typing of Cancers Workgroup (Campbell-Thompson). Human papillomavirus prevalence in oropharyngeal cancer before vaccine introduction, United States. Emerg Infect Dis. 2014 May;20(5):822-8. doi: 10.3201/eid2005.131311.
  13. Pugliese A, Vendrame F, Reijonen H, Atkinson MA, Campbell-Thompson M, Burke GW. New Insights on Human Type 1 Diabetes Biology: nPOD and nPOD-transplantation. Cur Diab Rep 2014 Oct;14(10):530. doi: 10.1007/s11892-014-0530-0. PMID: 25142715.
  14. Xue S, Posgai A, Wasserfall C, Myhr C, Campbell-Thompson M, Mathews CE, Brusko T, Rabinovitch A, Savinov A, Battaglia , Battaglia M, Schatz D, Haller M, Atkinson MA. Combination therapy reverses hyperglycemia in NOD mice with established type 1 diabetes. Diabetes. 2015 Nov;64(11):3873-84. doi: 10.2337/db15-0164. Epub 2015 Jul 16. PMID: 26185279
  15. Campbell-Thompson, M. Organ Donors: What Can They Tell Us About Type 1 Diabetes. Pediatr Diabetes. 2015 Aug;16(5):320-30. doi: 10.1111/pedi.12286. Review. PMID: 25998576
  16. Yoon Y.M., Jamal S Lewis, Matthew R Carstens, Campbell-Thompson, Clive H Wasserfall, Mark A Atkinson, Benjamin G. Keselowsky. Sci Rep 2015 Aug 17;5:13155. doi: 10.1038/srep13155.
  17. Burch, T.C., M.A. Morris, Campbell-Thompson, A. Pugliese, J.L. Nadler, J.O. Nyalwidhe. Proteomic Analysis of Healthy and Diabetic Disease Stratified Human Pancreas Tissues Reveal Potential Protein Signatures of Type 1 and Type 2 Diabetes. PLoS One 2015 Aug 24;10(8):e0135663. doi: 10.1371/journal.pone.0135663. eCollection 2015. PMID:26302420
  18. Jurczyk, A., A. Nowosielska, N. Przewozniak, K-E. Aryee, P. diIorio, D. Blodgett, C. Yang, M. Campbell-Thompson, M. Atkinson, L., A. Rittenhouse, D. Harlan, D. Greiner, and R. Bortelli. DISC1 beyond the brain: A Role for Disrupted in Schizophrenia 1 in Pancreatic β-cell Survival, Function and Glucose Homeostasis. FASEB J. 2016 Feb;30(2):983-93. doi: 10.1096/fj.15-279810. PMID: 26546129
  19. Campbell-Thompson, M, J.S. Kaddis, C. Wasserfall, M.J. Haller, A. Pugliese, D. Schatz, J.J. Shuster, M.A. Atkinson. The Influence of Type 1 Diabetes on Pancreatic Weight. 2016;59(1):217-21. Cover image.
  20. Campbell-Thompson M, Ann Fu, Clive Wasserfall, John Kaddis, Desmond Schatz, Alberto Pugliese, and Mark Atkinson. Insulitis and beta cell mass in the natural history of type 1 diabetes. Diabetes. 2016 Mar;65(3):719-31. doi: 10.2337/db15-0779 PMID: 26581594. Cover image.
  21. Campbell-Thompson, M, Rodriguez-Calvo, R, Battaglia, M. Abnormalities of the exocrine pancreas in type 1 diabetes. Curr Diab Rep.2015 Oct;15(10):79. doi: 10.1007/s11892-015-0653-y. PMCID: PMC5072278
  22. Laiho JE, Oikarinen M, Richardson SJ, Frisk G, Nyalwidhe J, Burch TC, Margaret Morris, Sami Oikarinen, Alberto Pugliese, Francesco Dotta, Martha Campbell-Thompson, Jerry Nadler, Noel Morgan, and Heikki Hyöty. Relative sensitivity of immunohistochemistry, MRM mass spectrometry, in situ hybridization and RT-PCR to detect Coxsackievirus B1 in A549 cells. J Clin Virol. 2016;77:21-8.
  23. Campbell-Thompson M, DA Schatz, J Kaddis, Atkinson MA. Pancreatic duct hyperplasia/dysplasia in type 1 diabetes and pancreatic weight in individuals with and without diabetes. Reply to Kobayashi T, Aida K, Fukui T et al [letter] and Saisho Y [letter]. Diabetologia 2016;59(4):870-2.
  24. Hackeng WM, Brosens LA, Poruk KE, Noë M, Hosoda W, Poling JS, Rizzo A, Campbell-Thompson M, Atkinson MA, Konukiewitz B, Klöppel G, Heaphy CM, Meeker AK, Wood LD. Aberrant Menin expression is an early event in pancreatic neuroendocrine tumorigenesis. Hum Pathol. 2016;56:93-100. PMID: 27342911
  25. Philips T, Kusmartseva I, Gerling IC, Campbell-Thompson M, Wasserfall C, Pugliese A, et al. Factors That Influence the Quality of RNA From the Pancreas of Organ Donors. Pancreas. 2017;46(2):252-9.
  26. Seay HR, Yusko E, Rothweiler SJ, Zhang L, Posgai AL, Campbell-Thompson M, Vignali M, Emerson RO, Kaddis JS, Ko D, Nakayama M, Smith MJ, Cambier JC, Pugliese A, Atkinson MA, Robins HS, Brusko TM. Tissue distribution and clonal diversity of the T and B cell repertoire in type 1 diabetes. JCI Insight. 2016;1(20):e88242. PMID: 27942583
  27. Jacobsen LM, Atkinson MA, Campbell-Thompson M, Schatz DA. Presumptive Type 1 Diabetes with Comorbidities and Rapid Progression Despite Numerous Insulin-Positive Islets. Diabetes Care 2016 Jul;39(7):1292-4. PMID:27330131
  28. Michels AW, Landry LG, McDaniel KA, Yu L, Campbell-Thompson M, Kwok WW, Jones KL, Gottlieb PA, Kappler JW, Tang Q, Roep BO, Atkinson MA, Mathews CE, Nakayama M. Islet-derived CD4 T-cells targeting proinsulin in human autoimmune diabetes. 2017;66(3):722-34. PMID:27920090
  29. Jacobsen LM, Posgai AL, Campbell-Thompson M, Schatz DA. Diagnostic Dilemma: Clinical and Histological Abnormalities in a Hispanic Patient With Diabetes. Diabetes Care. 2016;39(9):1650-2. PMID: 27555624
  30. Babon JA, DeNicola ME, Blodgett DM, Crèvecoeur I, Buttrick TS, Maehr R, Bottino R, Naji A, Kaddis J, Elyaman W, James EA, Haliyur R, Brissova M, Overbergh L, Mathieu C, Delong T, Haskins K, Pugliese A, Campbell-Thompson M, Mathews C, Atkinson MA, Powers AC, Harlan DM, Kent SC. Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes. Nat Med. 2017;23(2):264. PMID:27798614
  31. Campbell-Thompson ML, Atkinson MA, Butler AE, Giepmans BN, von Herrath MG, Hyöty H, et al. Re-addressing the 2013 consensus guidelines for the diagnosis of insulitis in human type 1 diabetes: is change necessary? Diabetologia. 2017 Apr;60(4):753-755. doi: 10.1007/s00125-016-4195-x. Epub 2017 Jan 9. PMID: 28070616
  32. Li X, Campbell-Thompson M, Wasserfall CH, McGrail K, Posgai A, Schultz AR, et al. Serum Trypsinogen Levels in Type 1 Diabetes. Diabetes Care. 2017;40(4):577-82
  33. Christian Mueller, Gwladys Gernoux, Alisha Gruntman, Florie Borel, Emer Reeves, Roberto Calcedo, Farshid Rouhani, Anthony Yachnis, Margaret Humphries, Campbell-Thompson, Louis Messina, Jeffrey Chulay, Bruce Trapnell, James Wilson, Noel McElvaney, and Terence Flotte. 5 Year Expression and Neutrophil Defect Repair after Gene Therapy in Alpha-1 Antitrypsin Deficiency. Molecular Therapy, 2017 Jun 7;25(6):1387-1394. doi: 10.1016/j.ymthe.2017.03.029. Epub 2017 Apr 10.
  34. Jackson J, Posgai A, Campbell-Thompson M, Kusmartseva I. Insulitis in an Autoantibody Positive Pancreatic Donor with History of Gestational Diabetes Mellitus. Diabetes Care. 2017 May;40(5):723-725. doi: 10.2337/dc16-2127. PMID: 28428323 PMCID: PMC5399650 DOI:10.2337/dc16-2127
  35. Jacobsen, LM, Haller MJ, Parrish A, Levine SR, Wasserfall C, Campbell-Thompson M, Kaddis J, Pugliese A, Atkinson MA, Schatz D. High illicit drug abuse and suicide in organ donors with type 1 diabetes. Diabetes Care, 2017 Jul 5. pii: dc170996. doi: 10.2337/dc17-0996. [Epub ahead of print]
  36. Wasserfall C, Nick HS, Campbell-Thompson M, Beachy D, Haataja L, Kusmartseva I, Posgai A, Beery M, Rhodes C, Bonifacio E, Arvan P, Atkinson M. Persistence of pancreatic insulin mRNA expression and proinsulin protein in type 1 diabetes pancreata. Cell Metabolism, 2017 Sep 5;26(3):568-575.e3. doi: 10.1016/j.cmet.2017.08.013.
  37. Sanyoura M, Jacobsen L, Carmody D, Gaudio DD, Alkorta-Aranburu G, Arndt K, Hu YY, Kobiernicki F, Kusmartseva I, Atkinson MA, Philipson LH, Schatz D, Campbell-Thompson M, Greeley SAW. Pancreatic Histopathology of Human Monogenic Diabetes Due to Causal Variants in KCNJ11, HNF1A, GATA6, and LMNA. J Clin Endocrinol Metab.2017 Aug 16. doi: 10.1210/jc.2017-01159. [Epub ahead of print].
  38. Butterworth E, Dickerson WD, Vijay V, Weitzel K, Cooper J, Atkinson EW, Coleman JE, Otto KJ, Campbell-Thompson M. High resolution 3D Imaging of the Human Pancreas Neuro-Insular Network. J Vis Exp. 2018 Jan 29;(131). doi: 10.3791/56859.2018. PMID: 29443037.
  39. Brissova, M, Chunhua Dai, David Blodgett, Rita Bottino, Campbell-Thompson, Radhika Aramandla, Gregory Poffenberger, Fong Cheng Pan, Matthias G. von Herrath, Mark Atkinson, David M. Harlan, Roland Stein, Alvin C. Powers. Pancreatic islets in recent-onset type 1 diabetes have remnant β cells with normal gene expression and function, but the function and gene expression of α cells is abnormal. Cell Rep.2018 Mar 6;22(10):2667-2676. doi: 10.1016/j.celrep.2018.02.032.
  40. Zhu Y, Piehowski PD, Zhao R, Chen J, Shen Y, Moore RJ, Shukla AK, Petyuk VA, Campbell-Thompson M, Mathews CE, Smith RD, Qian WJ, Kelly RT. Nanodroplet processing platform for deep and quantitative proteome profiling of 10-100 mammalian cells. Nat Commun. 2018 Feb 28;9(1):882. doi: 10.1038/s41467-018-03367-w. PMID: 29491378
  41. Canzano J, Butterworth E, Fu A, Atkinson M, Campbell-Thompson M. Endocrine microvascular changes in human type 1 diabetes. J Histochem Cytochem.2018 May 1:22155418778546. doi: 10.1369/0022155418778546.
  42. Maarit Oikarinen, Jutta E. Laiho, Sami Oikarinen, Sarah J. Richardson, Irina Kusmartseva, Martha Campbell-Thompson, Noel G. Morgan, Alberto Pugliese, Sisko Tauriainen, Antonio Toniolo, Heikki Hyöty and the nPOD and PEVNET study groups. Detection of enterovirus protein and RNA in multiple tissues from nPOD organ donors with type 1 diabetes. BioRxiv, 2019.
  43. Tang, S-C. Jessup, CF, Campbell-Thompson, M. The role of accessory cells in islet homeostasis. Current Diabetes Reports: Type 1 Diabetes Pathogenesis. 2018 Sep 28;18(11):117. doi: 10.1007/s11892-018-1096-z.
  44. Campbell-Thompson M, Filipp SL, Grajo, JR, Nambam B, Beegle R, Middlebrooks EH, Gurka MJ, Atkinson MA, Schatz DA, Haller MJ. Relative Pancreas Volume is Reduced in First-Degree Relatives of Patients with Type 1 Diabetes. Diabetes Care.  2018 Dec 14. pii: dc181512. doi: 10.2337/dc18-1512.
  45. Beery ML, Jacobsen LM, Atkinson MA, Butler AE, Campbell-Thompson M. Islet amyloidosis in a child with type 1 diabetes. 2019;11(2):44-49. doi: 10.1080/19382014.2019.1599707. Epub 2019 May 14. PubMed PMID: 31084520; PubMed Central PMCID: PMC6548483.
  46. Kusmartseva I, Beery M, Hiller H, Padilla M, Selman S, Posgai A, Nick HS, Campbell-Thompson M, Schatz DA, Haller MJ, Wasserfall CH, Atkinson MA. Temporal Analysis of Amylase Expression in Control, Autoantibody-Positive, and Type 1 Diabetes Pancreatic Tissues. 2020 Jan;69(1):60-66. doi: 10.2337/db19-0554. Epub 2019 Oct 9. PubMed PMID: 31597639; PubMed Central PMCID: PMC6925584.
  47. Bray JK, Elgamal OA, Jiang J, Wright LS, Sutaria DS, Badawi M, Borcyk MG, Liu X, Fredenburg KM, Campbell-Thompson ML, Schmittgen TD. Loss of RE-1 silencing transcription factor accelerates exocrine damage from pancreatic injury. Cell Death Dis. 2020 Feb 20;11(2):138. doi: 10.1038/s41419-020-2269-7. PMID: 32080178
  48. Pascal de Boer, Nicole Pirozzi, Anouk H. G. Wolters, Jeroen Kuipers, Irina Kusmartseva, Mark Atkinson, and Martha Campbell-Thompson, Ben Giepmans. Large-scale electron microscopy database for human type 1 diabetes. Nature Communications, 2020 May 18;11(1):2475. doi: 10.1038/s41467-020-16287-5.
  49. Mark Atkinson, Martha Campbell-Thompson, Irina Kusmartseva, Klaus H. Kaestner. Organisation of the human pancreas in health and in diabetes. Diabetologia, 63 (10): 1966-1973, 2020.
  50. Timothy P. Foster, Brittany Bruggeman, Martha Campbell-Thompson, Mark A. Atkinson, Michael J. Haller, Desmond A. Schatz. Exocrine Pancreas Dysfunction in Type 1 Diabetes. Endocr Pract. 2020 Dec;26(12):1505-1513. doi: 10.4158/EP-2020-0295. PMID: 33471743 Review.
  51. Carr ALJ, Perry DJ, Lynam AL, Chamala S, Flaxman CS, Sharp SA, Ferrat LA, Jones AG, Beery ML, Jacobsen LM, Wasserfall CH, Campbell-Thompson ML, Kusmartseva I, Posgai A, Schatz DA, Atkinson MA, Brusko TM, Richardson SJ, Shields BM, Oram RA. Histological validation of a type 1 diabetes clinical diagnostic model for classification of diabetes Diabet Med. 2020 Dec;37(12):2160-2168. doi: 10.1111/dme.14361. Epub 2020 Jul 23.PMID: 32634859.
  52. Shapiro MR, Yeh WI, Longfield JR, Gallagher J, Infante CM, Wellford S, Posgai AL, Atkinson MA, Campbell-Thompson M, Lieberman SM, Serreze DV, Geurts AM, Chen YG, Brusko TM. CD226 Deletion Reduces Type 1 Diabetes in the NOD Mouse by Impairing Thymocyte Development and Peripheral T Cell Activation. Front Immunol. 2020 Sep 4;11:2180. doi: 10.3389/fimmu.2020.02180. eCollection 2020. PMID: 33013915
  53. Dirr EW, Urdaneta ME, Patel Y, Johnson RD, Campbell-Thompson M, Otto KJ. Designing A Bioelectronic Treatment For Type 1 Diabetes: Targeted Parasympathetic Modulation of Insulin Secretion. Bioelectron Med (Lond). 2020 Jul;3(2):17-31. doi: 10.2217/bem-2020-0006. Epub 2020 Jul 28.PMID: 33169091 Review.
  54. Tang X, Kusmartseva I, Kulkarni S, Posgai A, Speier S, Schatz DA, Haller MJ, Campbell-Thompson M, Wasserfall CH, Roep BO, Kaddis JS, Atkinson MA. Image-Based Machine Learning Algorithms for Disease Characterization in the Human Type 1 Diabetes Pancreas. Am J Pathol. 2020 Dec 8:S0002-9440(20)30551-4. doi: 10.1016/j.ajpath.2020.11.010. Online ahead of print. PMID: 33307036
  55. Kusmartseva I, Wu W, Syed F, Van Der Heide V, Jorgensen M, Joseph P, Tang X, Candelario-Jalil E, Yang C, Nick H, Harbert JL, Posgai AL, Paulsen JD, Lloyd R, Cechin S, Pugliese A, Campbell-Thompson M, Vander Heide RS, Evans-Molina C, Homann D, Atkinson MA. Expression of SARS-CoV-2 Entry Factors in the Pancreas of Normal Organ Donors and Individuals with COVID-19. Cell Metab. 2020 Dec 1;32(6):1041-1051.e6. doi: 10.1016/j.cmet.2020.11.005. Epub 2020 Nov 13. PMID: 33207244.
  56. Ross JJ, Wasserfall CH, Bacher R, Perry DJ, McGrail K, Posgai AL, Dong X, Muir A, Li X, Campbell-Thompson M, Brusko TM, Schatz DA, Haller MJ, Atkinson MA. Exocrine Pancreatic Enzymes Are a Serological Biomarker for Type 1 Diabetes Staging and Pancreas Size. 2021 Jan 13:db200995. doi: 10.2337/db20-0995. Online ahead of print. PMID: 33441381
  57. Campbell-Thompson M, Butterworth, E.A., Boatwright, J.L., Nair, M.A., Nasif, L. H., Nasif, K., Revell, A.Y., Riva, A., Mathews, C. E., Gerling, I. C., Schatz, D.A., Atkinson, M.A. Islet sympathetic neuroanatomy in human type 1 diabetes. Scientific Reports, 2021 Mar 22;11(1):6562. PMID: 33753784 PMCID: PMC7985489 DOI: 1038/s41598-021-85659-8
  58. Campbell-Thompson M, Tang S-C. Human pancreas optical clearing and microscopy. Pancreas Imaging Across the Spectrum. Frontiers Endocrinology. In press, invited review.